Price Comparisons for dermalone ointment

 

dermalone ointment

Dermalone Ointment is useful in the treatment of acute and chronic otitis of varied etiologies, in interdigital cysts in cats and dogs, and in anal gland infections in dogs. The preparation is also indicated in the management of dermatologic disorders characterized by inflammation and dry or exudative dermatitis, particularly those caused, complicated, or threatened by bacterial or candidal (Candida albicans) infections. It is also of value in eczematous dermatitis, contact dermatitis, and seborrheic dermatitis; and as an adjunct in the treatment of dermatitis due to parasitic infestation. 

Description

Dermalone Ointment is a combination of nystatin, neomycin sulfate, thiostrepton and triamcinolone acetonide in a non-irritating vehicle, a polyethylene and mineral oil gel base.

Each mL contains:

nystatin

100,000 Units

neomycin sulfate (equivalent to neomycin base)

2.5 mg.

thiostrepton

2,500 Units

triamcinolone acetonide

1.0 mg.

Dermalone Ointment is supplied in tubes of 1/4 fl. oz. (7.5 mL), 1/2 fl. oz. (15 mL), and 1 fl. oz. (30 mL), each with an elongated tip for easy and in dispensing bottles of 8 fl. oz. (240 mL). The preparation is intended for local therapy in a variety of cutaneous disorders of cats and dogs; it is especially useful in disorders caused, complicated or threatened by bacterial and/or candidal (monilial) infections.

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By virtue of its four active ingredients, the ointment provides four basic therapeutic effects: anti-inflammatory, antipruritic, antifungal and antibacterial. Triamcinolone acetonide is a potent synthetic corticosteroid providing rapid and prolonged symptomatic relief on topical administration. Inflammation, edema and pruritus promptly subside and lesions are permitted to heal. Nystatin is the first well-tolerated anti-fungal antibiotic of  efficacy for the treatment of cutaneous infection caused by Candida albicans (monilia). Nystatin is fungistatic in vitro against a variety of yeast and yeast-like fungi including many fungi pathogenic to animals. No appreciable activity is exhibited against bacteria. Thiostrepton has a high order of activity against gram-positive organisms, including many which are resistant to other antibiotics; neomycin exerts antimicrobial action against a wide range of gram-positive and gram-negative bacterial. Together they provide comprehensive therapy against organisms  for most superficial bacterial infections.

Dermalone Ointment Indications

Dermalone Ointment is particularly useful in the treatment of acute and chronic otitis of varied etiologies, in interdigital cysts in cats and dogs, and in anal gland infections in dogs. The preparation is also indicated in the  of dermatologic disorders characterized by inflammation and dry or exudative dermatitis, particularly those caused, complicated, or threatened by bacterial or candidal (Candida albicans) infections. It is also of value in eczematous dermatitis, contact dermatitis, and seborrheic dermatitis; and for use as an adjunct in the treatment of dermatitis due to parasitic infection.

Warning

Clinical and experimental  have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis.

Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in the offspring. In dogs, other congenital anomalies have resulted; deformed forelegs, phocomelia, and anasarca.

Precautions

Dermalone Ointment is not intended for the treatment of deep abscesses or deep-seated infections such as inflammation of the lymphatic vessels. Parenteral antibiotic therapy is indicated in these infections. Dermalone Ointment (Nystatin-Neomycin Sulfate-Thiostrepton-Triamcinolone Acetonide Ointment) has been extremely well tolerated. Cutaneous reactions attributable to its use have been extremely rare. The occurrence of systemic reaction is rarely a problem with topical administration.

There is some evidence that corticosteroids can be absorbed after topical application and cause systemic effects. Therefore, an animal receiving Dermalone Ointment therapy should be observed closely for signs such as polydipsia, polyuria, and increased weight gain. Dermalone Ointment is not generally recommended for the treatment of deep or puncture wounds or serious burns.

Sensitivity to neomycin may occur. If redness, irritation or swelling persists or increases, discontinue use. Do not use if pus is present since the drug may allow the infection to spread. Keep this and all medications out of the reach of children.

Avoid ingestion. Oral or parental use of corticosteroids ( dose, duration of use, and specific steroid) may result in inhibition of endogenous steroid production following drug withdrawal.

Side Effects

SAP and SGPT (ALT) enzyme elevations, polydipsia/polyuria, vomiting, and diarrhea (occasionally bloody) have been observed following parenteral or systemic use of synthetic corticosteroids in dogs.

Cushing's syndrome has been reported in association with prolonged or repeated steroid therapy in dogs.

Temporary hearing  has been reported in conjunction with treatment of otitis with products containing corticosteroids. However, regression usually occurred following withdrawal of the drug. If hearing dysfunction is noted during the course of treatment with Dermalone Ointment, discontinue its use.

Dermalone Ointment Caution

Before instilling any medication into the ear, examine the external ear canal thoroughly to be certain the tympanic membrane is not ruptured in order to avoid the possibility of transmitting infection to the middle ear as well as damaging the cochlea or vestibular apparatus from prolonged contact. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue the use of Dermalone Ointment.

Dosage and Administration

Frequency of administration is dependent on the severity of the condition. For mild inflammations, application may range from once daily to once a week; for severe conditions Dermalone Ointment may be applied as often as two to three times daily, if necessary. Frequency of treatment may be decreased as improvement occurs.

Wear gloves during the administration of the ointment or wash hands immediately after application.

Otitis: Clean ear canal of impacted cerumen. Inspect canal and remove any foreign bodies such as grass lawns, ticks, etc. Instill three to five drops of Dermalone Ointment.

Preliminary use of a local anesthetic such as Proparacaine Hydrochloride Ophthalmic may be advisable.

Infected Anal Glands, Cystic Areas, etc.:

Drain gland or cyst and then fill it with Dermalone Ointment.

Other Dermatologix Disorders:

Clean affected areas, removing any encrusted discharge or exudate. Apply Dermalone Ointment (Nystatin-Neomycin Sulfate-Thiostrepton-Triamcinolone Acetonide Ointment) sparingly in a thin film.

Storage

240 mL Bottle. Do not store above 86° F. 7.5 mL, 15 mL, 30 mL tubes: Store at room temperature; avoid excessive heat (104° F).