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disal

Disal Injection 50mg 100ml is an effective diuretic-saluretic for use in the treatment of acute noninflammatory tissue edema in dogs and horses, and for use in the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency in the dog. In cases of edema involving cardiac insufficiency, the continued use of heart stimulants such as digitalis or its glycosides is indicated.

 

The rationale for efficacious use of diuretic therapy in either dogs or horses is determined by the clinical pathology producing the edema.

For: Dogs & Horses

Dosage and Administration:

Dogs — Administer intravenously or intramuscularly 0.25 to 0.50 mL per 10 pounds body weight once or twice daily at 6 to 8 hour intervals.

The dosage should be adjusted to the individual’s response. In severe edematous or refractory cases, the dose may be doubled or increased by increments of 1.0 mg per pound of body weight. The established effective dose should be administered once or twice daily. Discontinue diuretic therapy with Disal Injection, 50 mg/mL after initiation of acute fluid mobilization or stabilization of patient; when necessary Disal Tablets may be used for maintenance therapy (see Disal Tablets insert for details). Do not exceed treatment with Disal Injection, 50 mg/mL for more than 3 days. The daily schedule of administration can be timed to control the period of micturition for the convenience of the client or veterinarian. Mobilization of the edema may be most efficiently and safely accomplished by utilizing an intermittent daily dose schedule, i.e., every other day or 2 to 4 consecutive days weekly.

Horses — The usual parenteral dosage of furosemide in horses is approximately 0.5 mg/lb body weight (1.0 mg/kg). See dosage schedule below. A prompt diuresis usually ensues from the initial treatment. Administer once or twice daily at 6 to 8 hour intervals either intravenously or intramuscularly until desired results are achieved.

The dosage should be adjusted to the individual’s response. In severe edematous or refractory cases, the dose may be doubled or increased by increments of 0.5 mg per pound of body weight. The established effective dose should be administered once or twice daily. The daily schedule of administration can be timed to control the period of micturition for the convenience of the client or veterinarian. Mobilization of the edema may be most efficiently and safely accomplished by utilizing an intermittent daily dose schedule, i.e., every other day or 2 to 4 consecutive days weekly.

Recommended Dosage Schedule

Horses: Administer IV or IM once or twice daily at 6-8 hour intervals until desired results are achieved.

Body Weight (lbs) Disal Injections (50mg/ml)
500 4.6 ml
600 5.5 ml
700 6.4 ml
800 7.3 ml
900 8.2 ml
1000 9.1 ml
1100 10.0 ml
1200 10.9 ml

Diuretic therapy for both dogs and horses should be discontinued after reduction of the edema, or maintained after determining a carefully programmed dosage schedule to prevent recurrence of edema. For long-term treatment, the dose can generally be lowered after the edema has once been reduced. Re-examination and consultations with the client will enhance the establishment of a satisfactorily programmed dosage schedule. Clinical examination and serum BUN, CO2 and electrolyte determinations should be performed during the early period of therapy and periodically thereafter, especially in refractory cases. Abnormalities should be corrected or the drug temporarily withdrawn.